The Japanese Approach to Immunity
💡 In the Japanese understanding, immunity is not just the ability to avoid illnesses. It is part of the philosophy of ME-BYO (mibyō), or the "state between health and illness." The Japanese believe it's better to notice and correct an imbalance at an early stage than to treat a fully developed disease. Immunity here is not a passive shield, but an active system that can and should be trained.
Professor Ken Ishii, head of the Division of Vaccinology at the Institute of Medical Science, University of Tokyo, explains: "The immune system is not just a collection of cells, but a complex network of interactions. Understanding how cells communicate with each other opens up new possibilities for prevention and treatment."
A research group led by Professor Ishii recently made a breakthrough by discovering a new cellular phenomenon — nucleocytosis. This is a process where immune cells extract nuclear DNA from dying cells in a controlled manner, without destroying the nuclear envelope. The discovery, published in Nature Communications in February 2026, forces a reassessment of how one's own DNA activates the immune response and opens new perspectives for treating autoimmune diseases and cancer.
Traditional Japanese Practices for Immunity Strengthening
It is important to understand the lifestyle that creates the foundation for strong immunity before discussing supplements.
Shinrin-yoku — Forest Bathing
There is an official therapeutic practice in Japan called shinrin-yoku ("forest bathing"), which has been part of the national health program since the 1980s.
How it works:
- After just 20 minutes in the forest, cortisol (stress hormone) levels drop, pulse slows down, and blood pressure decreases.
- Trees emit phytoncides — volatile substances that stimulate the production of NK cells (natural killers) responsible for fighting viruses and abnormal cells.
- Regular practice improves sleep, concentration, and alleviates symptoms of chronic fatigue.
Which trees are most beneficial:
- Conifers (pine, fir) — sources of alpha-pinene with antibacterial effects.
- Birch and linden — aid recovery after colds.
- Oak — beneficial for hypertension.
Thermal Processing of Food
The Japanese rarely eat cold food. Even in summer, preference is given to warm dishes that do not stress the digestive system and do not require additional energy expenditure for warming.
Fermented Foods
Miso, natto, kimchi (Japanese version), soy sauce — all are fermented foods rich in probiotics. They support the gut microbiota, and 70% of immune cells are located precisely in the gut.
Key Components for Immunity: What the Japanese Take
Lactic Acid Bacteria Lactobacillus Plasma
What it is:
Lactococcus lactis Strain Plasma (LC-Plasma) is a unique strain of lactic acid bacteria developed by Kirin. Its special feature is its ability to activate plasmacytoid dendritic cells (pDCs) — the main regulators of the immune response.
Proven effectiveness:
A study by Kirin Holdings, presented at the 20th Asia-Pacific Congress of Clinical Microbiology and Infectious Diseases in November 2025, showed:
- LC-Plasma suppresses the replication of influenza virus (H1N1) and SARS-CoV-2.
- Previously, its effect against dengue, chikungunya, Zika, and rotaviruses was proven.
- The effect is based on the activation of interferon-alpha (IFN-α) — a key component of antiviral defense.
A 2024 study in the journal Microorganisms confirmed that stimulating immune cells with LC-Plasma suppresses the replication of dengue, chikungunya, and Zika viruses by activating the IFN-α signaling pathway.
Conclusion: LC-Plasma may be effective against at least six types of viruses, making it a versatile preventive agent.
Product example: Kirin Lactic Acid Bacteria Lactobacillus Plasma for Immunity Strengthening
Vitamin D3 — The Sunshine Immunomodulator
Why it's needed:
Vitamin D is involved in regulating over 200 genes, including those responsible for the immune response. Vitamin D deficiency is directly linked to an increased risk of infectious diseases.
Modern research:
A systematic review of randomized controlled trials (Abboud et al.) showed that taking vitamin D and probiotics together provides greater health benefits than taking them separately:
- Improvement of metabolic parameters (insulin sensitivity)
- Correction of dyslipidemia
- Reduction of inflammation
- Enhancement of antioxidant defense
📌 Combination with propolis and bifidobacteria enhances the immunomodulatory effect and provides comprehensive protection.
Product example: Highly Concentrated Vitamin D3 with Propolis and Bifidobacteria V.D3 2500 IU
Squalene — Oxygen Reserve and Immune Support
What it is:
Squalene is a natural hydrocarbon first isolated from the liver of deep-sea sharks. Its structure is similar to human sebum and it plays a key role in saturating cells with oxygen.
Why it's needed for immunity:
- Stimulates antibody production
- Enhances macrophage activity
- Has antioxidant action
- Supports tissue regeneration
- Improves oxygen delivery to cells, which is critically important for the immune response
📌 Japanese squalene is considered the gold standard of purity. Orihiro uses 100% freshly processed oil from deep-sea shark liver with a squalene content of 99.6%.
Composition of Orihiro product:
- 6 capsules contain 1800 mg of refined shark liver oil
- Additionally contains vitamins A, D, E
Usage recommendations:
- Adults: 2 capsules 3 times a day after meals
- Children: 1 capsule 3 times a day
Product example: 100% Squalene from Shark Liver for Immunity Orihiro
Euglena (Mizukawamo) — Unicellular Algae with a Complete Set of Nutrients
What it is:
Euglena (Euglena gracilis) is a unique microorganism combining plant and animal properties. It contains chlorophyll (like plants) and can move (like animals). Japanese scientists call it the "ideal superfood."
Why it's needed for immunity:
- Contains 59 types of nutrients (vitamins, minerals, amino acids, fatty acids)
- Rich in paramylon (beta-glucan), which activates immune cells
- Supports detoxification and liver function
- Improves energy metabolism
Research:
Euglena has been studied in Japan for decades. It is included in the list of "Foods for Specified Health Uses" and is recommended for immune support, especially during periods of high stress.
Product example: FMG Mission Euglena Complex for Body Protection and Health Strengthening
Fermented Black Garlic and Vinegar Extract
What it is:
Fermented black garlic is ordinary garlic that has undergone a long fermentation process under controlled temperature and humidity. As a result, it loses its pungent smell and taste but greatly enhances its beneficial properties.
Why it works:
- The concentration of polyphenols increases 5-7 times.
- Bioavailable forms of antioxidants are produced.
- The irritating effect on the gastrointestinal tract is reduced.
Black vinegar (kurokasu) is a traditional Japanese product made from fermented rice. It contains amino acids, organic acids, and minerals.
Combination:
The combination of fermented garlic and vinegar extract provides a synergistic effect:
- Powerful antioxidant protection
- Support for the cardiovascular system
- Strengthening immunity
- Reducing fatigue
Product example: Kobayashi Aged Black Garlic + Moromi Black Vinegar Health Strengthening Complex
📌 The manufacturer (Kobayashi Pharmaceutical) uses only garlic from Aomori Prefecture, known for its quality. The product contains no colorants, flavorings, or preservatives.
External Protection: Barrier Methods
The Japanese take a comprehensive approach to protection: not only "from the inside" (supplements) but also "from the outside" (barrier methods).
Virus and Allergen Blocker
How it works:
The spray creates a thin veil of positively charged polymers on the skin, which prevents viruses and allergens from adsorbing onto the skin.
Composition:
- Positively charged polymer (creates a protective barrier)
- Hyaluronic acid (moisturizes and prevents dryness)
- Water
Features:
- Safe for children and pregnant women
- Can be applied over makeup
- Does not cause tearing
- One bottle lasts for 160 applications
User reviews:
- "The scent is pleasant, almost imperceptible."
- "We use it, we like it."
- "Japan — super quality."
Product example: FUMAKILLA Kafun Virus and Allergen Blocker with Hyaluronic Acid
Comparison Table: Choosing Your Immune Complex
| Product | Key Components | Mechanism of Action | Who It's For |
| Kirin Lactobacillus Plasma | LC-Plasma lactic acid bacteria | Activation of pDCs, production of IFN-α | For virus protection, seasonal prevention |
| V.D3 2500 IU | Vitamin D3, propolis, bifidobacteria | Immunomodulation + probiotics | For vitamin D deficiency, comprehensive support |
| Orihiro Squalene | 99.6% squalene from shark liver | Macrophage activation, antioxidant | For energy and immunity, regeneration |
| FMG Mission Euglena | Euglena, 59 nutrients | Paramylon activates immunity | For high stress, nutritional replenishment |
| Kobayashi Black Garlic | Fermented garlic, vinegar extract | Polyphenols, antioxidants | For cardiovascular system and immunity |
| FUMAKILLA Kafun | Positively charged polymer + hyaluronic acid | Barrier protection | For daily protection against viruses and allergens |
Scientific Research: What Scientists Say
Kirin Holdings Study (2025)
Objective: To study the antiviral properties of Lactococcus lactis Strain Plasma.
Results: LC-Plasma suppresses the replication of influenza virus (H1N1) and SARS-CoV-2. The effect is dose-dependent and related to the activation of interferon-alpha.
Conclusion: LC-Plasma may be effective for the prevention of a wide range of respiratory viral infections.
Abboud et al. Study (Systematic Review)
Objective: Analysis of 7 randomized controlled trials on the combined intake of vitamin D and probiotics.
Results: The combination provided greater health benefits than taking them separately, including improvement of metabolic parameters, reduction of inflammation, and enhancement of antioxidant defense.
Conclusion: Combined intake of vitamin D and probiotics may be recommended for comprehensive immune support.
Shinrin-yoku Research
Objective: Determining the effect of forest walks on immunity (long-term observations).
Results: Regular "forest bathing" increases NK cell activity and reduces stress levels.
Conclusion: Shinrin-yoku is an accessible and effective method for strengthening immunity, recognized at the state level in Japan.
Discovery of Nucleocytosis (University of Tokyo, 2026)
Research led by Professor Ken Ishii identified a new cellular phenomenon — nucleocytosis.
Essence of the discovery: Immune cells can selectively extract nuclear DNA from dying cells in a controlled manner, without destroying the nuclear envelope.
Significance: This discovery changes the understanding of how one's own DNA activates the immune response and opens new perspectives for treating autoimmune diseases and cancer.
How the Japanese Build Immune Defense: Practical Schemes
Daily Base (Year-round)
- Proper nutrition with an emphasis on fermented foods.
- Warm water in the morning to kickstart metabolism.
- Nature walks (shinrin-yoku) at least twice a week.
- Basic supplements — squalene or euglena for general tone.
Seasonal Boost (Autumn-Winter)
- Lactobacillus Plasma — to activate antiviral immunity.
- Vitamin D3 + probiotics — comprehensive protection.
- Black garlic — antioxidant support.
- Barrier protection — FUMAKILLA spray before leaving home.
At the First Signs of Illness
- Increase dosage of vitamin D and probiotics.
- Squalene to support regeneration.
- Plenty of warm drinks.
- Rest and stress minimization.
For Travel and High Stress
- FUMAKILLA Kafun — in the pocket for quick protection.
- Euglena complex — for rapid nutrient replenishment.
Expert Opinions
✔️ Professor Ken Ishii, Institute of Medical Science, University of Tokyo:
"The immune system is not a passive shield, but an active network of interactions. Our recent discovery of nucleocytosis shows that we still do not know all the mechanisms of immune defense. But it is already clear: supporting immunity must be comprehensive — from lifestyle to properly selected supplements."
✔️ Professor Keiko Asakura, Toho University:
"Regular consumption of fortified foods and dietary supplements helps achieve adequate intake of vitamins and minerals without a significant risk of overdose. It is important to choose high-quality products from trusted manufacturers."
Frequently Asked Questions (FAQ)
❓ Can I take several immune supplements at the same time?
Answer: Yes, but considering compatibility. LC-Plasma, squalene, and vitamin D combine well and work through different mechanisms. Probiotics are best taken separately from antibiotics and with an interval of 2-3 hours.
❓ Is there a risk of overdose?
Answer: For water-soluble vitamins, the risk is minimal. For fat-soluble ones (D), it's important to follow dosages. Squalene is considered safe, but it's recommended to start with small doses.
❓ What is the best time to take them?
Answer:
- LC-Plasma and probiotics — in the morning before or with food.
- Vitamin D and squalene — with a meal containing fats.
- Black garlic — with meals.
- FUMAKILLA spray — before leaving home and during the day up to 5 times.
❓ Do I need to take breaks?
Answer: For preventive courses, it is recommended to take for 1-2 months with a break of 2-4 weeks. During cold and flu season, you can take continuously for up to 3 months.
❓ Can Japanese supplements be combined with medications?
Answer: With caution. Squalene may enhance the effect of blood-thinning medications. For chronic diseases and medication use, consultation with a doctor is necessary.
❓ Are these supplements safe for children?
Answer: Orihiro squalene is allowed for children from 3 years old (1 capsule 3 times a day). FUMAKILLA spray is safe for children. For other supplements, consultation with a pediatrician is recommended.
❓ How long does it take to see an effect?
Answer:
- LC-Plasma — activates immunity within a few days.
- Vitamin D — requires 2-4 weeks to replenish deficiency.
- Squalene and euglena — effect accumulates over 1-2 months.
- FUMAKILLA — works immediately, creating a barrier.
The Japanese Approach to Maintaining Immunity
The Japanese approach immunity systematically, combining:
- Thousand-year-old traditions (shinrin-yoku, fermented foods).
- Cutting-edge scientific developments (Lactobacillus Plasma, nucleocytosis).
- High-quality supplements (squalene, euglena, vitamin D).
- Barrier protection (sprays and blockers).
Key Principles of Japanese Immune Defense:
- Prevention, not treatment — the ME-BYO concept, identifying imbalance at an early stage.
- Comprehensiveness — working both from the inside and the outside.
- Quality — strict control at all production stages.
- Regularity — supplements are taken in courses, not sporadically.
- Scientific validity — research underpins each supplement.
💡 As Professor Ishii says: "Immunity is not magic, but science. Understanding the mechanisms allows us to strengthen our defense consciously."
Where to Buy Japanese Immunity Products
Our catalog of immunity products features all the products described, as well as a wide selection of other items.
Each product is shipped directly from Japan with a guarantee of authenticity and valid expiration dates.
Choose your complex and build your immunity consciously!
📌 This article is for informational purposes only. It is recommended to consult with a physician before starting any dietary supplements.